Technology & innovation

Now in production, Hyamatrix bio skin set to improve lives and defy ageing

25 Nov '11
Oleg Kouzbit, Online News Managing Editor

Orenburg’s revolutionary Hyamatrix bio skin is hitting domestic and international biomed markets. A multipartite, three-year effort by scientific researchers and entrepreneurs, the Hyamatrix project aims to soothe the sufferings of burn patients, help the wounded and scarred, and excite millions of women by smoothing away wrinkles and cellulite and re-granting their skin the comeliness of a younger age.

An advanced bio skin called the Hyamatrix has finally gone into commercial production in Orenburg, three years after scientist Ramil Rakhamatullin developed this next gen hyaluronic acid based technology as an innovative response to pent-up demand for higher-quality burn and ulcer treatment and skin rejuvenation.

The product developer and his team claim the new bio skin effectively remedies skin and mucous tunic defects caused by burns, traumas, trophic ulcers, etc. while showing enhanced biocompatibility and affecting no surrounding tissue or organs.

With its regenerative powers the innovation also fights skin ageing, they say. Hyamatrix-based cosmetics is believed to not only smooth away external senescence manifestations like wrinkles but also effectively rein in the ageing process, helping skin cells shed “a few years” off their biological age.

The technology is also said to be helpful in keeping at bay one of women’s most dreaded banes—cellulite.

To launch and then ramp up production of the new family of bioplastic nanostructured materials start-up Biomateria has been established. The company will reportedly start by making 1,500 Hyamatrix packages a month, and then expand to sell $3-5m worth of products a year to hospitals and cosmetic clinics both domestically and internationally.

The team of players

Biomateria is Orenburg State University’s spin-off technology start-up and also a subsidiary of R&D company Nanosintez—a regional hi-tech pharma and bioengineering developer since 1999. Nanosintez already markets small-scale runs of hyaluronic acid based cosmetics and earlier this year shook hands with Italy’s Bisio Progetti over a $40m contract for prospective Hyamatrix distribution in the EU and the U.S.

Also teaming up for additional expertise are Orenburg State Medical Academy and the Matrix laser therapy center.

The prime mover behind the cutting-edge project is Ramil Rakhamatullin, an Orenburg-based scientist who leads a cell technology lab at Orenburg State University and is the Nanosintez CEO. His 2008 invention of the Hyamatrix bio skin received $156k support from the Bortnik Fund (Russia’s oldest government-run entity to finance small innovative companies), followed by a $165k grant from the Orenburg regional administration.

The seed capital enabled early-stage R&D and prototype development. In 2010, a private ‘smart money’ investor, ATS Capital, forked out more than $500k to tighten up the technology and outfit production premises. Now ATS Capital is Biomateria’s strategic partner in product promotion and marketing across Russia and beyond.

For its production start-up Nanosintez as a parent company wants to raise another $1m for expansion.

How it works

The new product is designed to inhibit skin ageing by impacting human metabolic activity and setting off collagen and elastin synthesis in derma.

The Hyamatrix bio skin is a bioplastic material, an elastic plate that is said to show superb adhesion and mechanical strength.

At the heart of the new polymer technology is photochemical nanostructuring, or photopolymerization, of basic hyaluronic acid hydrocolloid. Laser-phoresis is reportedly used to introduce low-molecular hyaluronic acid and a special bio skin matrix peptide into derma. Both are then photopolimerized by low-frequency laser and seamed on a molecular level right inside the skin treated.

In the process, hyaluronic acid is transformed into a high-molecular, 3D matrix skeleton believed to be “fully identical to intercellular matrix of a young person’s skin”—a major step forward from existing biomed solutions that the Hyamatrix designers claim lack in molecular weight and therefore can’t create a strong matrix skeleton for lasting effect.

No extra chemicals

According to the developers, photopolymerization calls for no extra chemical additives, making the method and the end product clinically purer.

When used on a wound, the Hyamatrix biomaterial doesn’t require any bandaging. It doesn’t have to be removed from the wound, either, as the innovative plate is biodegradable and resolves as the wound heals.

The approach is reportedly effective when applied to acne as well as keloid and hypertrophic scars.

The Hyamatrix for the burnt

As a lower-cost and less painful alternative to today’s treatments of burn patients Mr. Rakhamatullin hopes his Hyamatrix will find its way to hospitals’ burns departments both in Russia and abroad. The technology suits well for patients’ preoperative preparation and postoperative rehabilitation, he says.

In Russia, about 700,000 people suffer each year from severe burns, and only 23% of them are admitted to specialized burn centers to receive professional help.

Moscow’s Sklifosovsky Institute, Russia’s most renowned emergency care establishment, has already been purportedly testing the new bio skin to see if the technology can be adopted by burn centers across this country. The survivors of a Tupolev-134 jet crash that took 44 lives in Karelia in June 2011 are said to be convalescing with Hyamatrix plates in their skin.
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Locations: Orenburg

Tags: Hyamatrix (4) / bio skin (0) / Ramil Rakhamatullin (0) /

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